{"id":1847,"date":"2022-02-07T18:47:37","date_gmt":"2022-02-07T17:47:37","guid":{"rendered":"https:\/\/glycanostics.com\/?p=1847"},"modified":"2022-07-08T08:39:43","modified_gmt":"2022-07-08T06:39:43","slug":"detekcia-nn-diacetyllaktosaminu-lacdinac-s-obsahom-volneho-prostatickeho-specifickeho-antigenu-na-diagnostiku-rakoviny-prostaty-v-ranych-stadiach-ochorenia-a-identifikaciu-pacientov-s-karcinomom-pr","status":"publish","type":"post","link":"https:\/\/glycanostics.com\/sk\/detekcia-nn-diacetyllaktosaminu-lacdinac-s-obsahom-volneho-prostatickeho-specifickeho-antigenu-na-diagnostiku-rakoviny-prostaty-v-ranych-stadiach-ochorenia-a-identifikaciu-pacientov-s-karcinomom-pr\/","title":{"rendered":"Detekcia N,N-diacetyllaktosam\u00ednu (LacdiNAc) s obsahom vo\u013en\u00e9ho prostatick\u00e9ho \u0161pecifick\u00e9ho antig\u00e9nu na diagnostiku rakoviny prostaty v ran\u00fdch \u0161t\u00e1di\u00e1ch ochorenia a identifik\u00e1ciu pacientov s karcin\u00f3mom prostaty rezistentn\u00fdm na kastr\u00e1ciu"},"content":{"rendered":"\t\t
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Detekcia N,N-diacetyllaktosam\u00ednu (LacdiNAc) s obsahom vo\u013en\u00e9ho prostatick\u00e9ho \u0161pecifick\u00e9ho antig\u00e9nu na diagnostiku rakoviny prostaty v ran\u00fdch \u0161t\u00e1di\u00e1ch ochorenia a identifik\u00e1ciu pacientov s karcin\u00f3mom prostaty rezistentn\u00fdm na kastr\u00e1ciu<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prostate cancer (PCa) is one of the most common cancer types among men and also a common cause of death globally. With an increasing incidence, there is a need for low-cost, reliable biomarkers present in samples, which
could be provided non-invasively (without a need to perform prostate biopsy). Glycosylation changes of free-PSA (fPSA) are considered cancer-specific, while the level of different PSA forms can increase under other than
cancerous conditions. In the present study, we investigated the role of N,N-diacetyllactosamine (LacdiNAc) epitope of fPSA (i.e. glycoprofile of fPSA or gPSA) in combination with total-PSA (tPSA), prostate volume, and
tPSA density (tPSA level divided by prostate volume i.e. PSAd) as biomarkers for monitoring of PCa development and progression in 105 men. Furthermore, we applied an genetic (evolutionary) algorithm to identify any suspicious individuals in a benign cohort having benign prostatic hyperplasia (BPH). We identified 3 suspicious men originally diagnosed with BPH using gPSA analysis. In the follow-up we found out that two men should not be considered as BPH patients since multiparametric magnetic resonance imaging (mpMRI) identified one man with clinically significant PCa via Prostate Imaging \u2013 Reporting and Data System (PI RADS v2 = 4) and the second man
was with High-grade prostatic intraepithelial neoplasia (HG PIN), commonly described as a pre-cancerous stage. Moreover, in the study we described for the first time that changed LacdiNAc on PSA can be applied to identify
prostatitis patients and most importantly this is the first study suggesting that changed glycosylation on PSA can be applied to identify castration-resistant prostate cancer (CRPCa) patients.<\/p>

More info…<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Prostate cancer (PCa) is one of the most common cancer types among men and also a common cause of death globally. With an increasing incidence, there is a need for low-cost, reliable biomarkers present in samples, which could be provided non-invasively (without a need to perform prostate biopsy). Glycosylation changes of free-PSA (fPSA) are considered […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"inline_featured_image":false,"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"yoast_head":"\nDetekcia N,N-diacetyllaktosam\u00ednu (LacdiNAc) s obsahom vo\u013en\u00e9ho prostatick\u00e9ho \u0161pecifick\u00e9ho antig\u00e9nu na diagnostiku rakoviny prostaty v ran\u00fdch \u0161t\u00e1di\u00e1ch ochorenia a identifik\u00e1ciu pacientov s karcin\u00f3mom prostaty rezistentn\u00fdm na kastr\u00e1ciu - Glycanostics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0968089621001644\/?via=ihub\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Detekcia N,N-diacetyllaktosam\u00ednu (LacdiNAc) s obsahom vo\u013en\u00e9ho prostatick\u00e9ho \u0161pecifick\u00e9ho antig\u00e9nu na diagnostiku rakoviny prostaty v ran\u00fdch \u0161t\u00e1di\u00e1ch ochorenia a identifik\u00e1ciu pacientov s karcin\u00f3mom prostaty rezistentn\u00fdm na kastr\u00e1ciu - Glycanostics\" \/>\n<meta property=\"og:description\" content=\"Prostate cancer (PCa) is one of the most common cancer types among men and also a common cause of death globally. With an increasing incidence, there is a need for low-cost, reliable biomarkers present in samples, which could be provided non-invasively (without a need to perform prostate biopsy). 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