{"id":1849,"date":"2022-02-07T18:46:53","date_gmt":"2022-02-07T17:46:53","guid":{"rendered":"https:\/\/glycanostics.com\/?p=1849"},"modified":"2022-07-08T08:41:01","modified_gmt":"2022-07-08T06:41:01","slug":"analyza-seroveho-glykomu-pomocou-lektinovych-mikrocipov-u-pacientov-s-rakovinou-prostaty-hladanie-abnormalnych-glykoforiem","status":"publish","type":"post","link":"https:\/\/glycanostics.com\/sk\/analyza-seroveho-glykomu-pomocou-lektinovych-mikrocipov-u-pacientov-s-rakovinou-prostaty-hladanie-abnormalnych-glykoforiem\/","title":{"rendered":"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1849\" class=\"elementor elementor-1849\">\n\t\t\t\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-712f4996 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"712f4996\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-45f344eb\" data-id=\"45f344eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d3a952f elementor-widget elementor-widget-heading\" data-id=\"d3a952f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4eced7e2 elementor-widget elementor-widget-text-editor\" data-id=\"4eced7e2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tThis is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and 3 human lectins (17 lectins in total). Clinical validation of glycans as biomarkers was done in two studies: discrimination of healthy individuals with BPH patients vs. PCa patients (C vs. PCa) and discrimination of healthy individuals vs. BPH and PCa patients (H vs. PCond). Single lectins (17 lectins) and a combination of two lectins (136 binary lectin combinations) were applied in the clinical validation of glycan biomarkers providing 153 AUC values from ROC curves for both studies (C vs. PCa and H vs.\r\nPCond). Potential N- and O-glycans as biomarkers were identified and possible carriers of these glycans are shortly discussed.\r\n\r\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\" target=\"_blank\" rel=\"noopener\">More info&#8230;<\/a>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"inline_featured_image":false,"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[25],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem - Glycanostics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem - Glycanostics\" \/>\n<meta property=\"og:description\" content=\"This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/\" \/>\n<meta property=\"og:site_name\" content=\"Glycanostics\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-07T17:46:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-08T06:41:01+00:00\" \/>\n<meta name=\"author\" content=\"cagan@seesame.com\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Autor\" \/>\n\t<meta name=\"twitter:data1\" content=\"cagan@seesame.com\" \/>\n\t<meta name=\"twitter:label2\" content=\"Predpokladan\u00fd \u010das \u010d\u00edtania\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 min\u00fata\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/\",\"url\":\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/\",\"name\":\"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem - Glycanostics\",\"isPartOf\":{\"@id\":\"https:\/\/glycanostics.com\/#website\"},\"datePublished\":\"2022-02-07T17:46:53+00:00\",\"dateModified\":\"2022-07-08T06:41:01+00:00\",\"author\":{\"@id\":\"https:\/\/glycanostics.com\/#\/schema\/person\/badee4cbfc54e0bf99314635b428c54d\"},\"breadcrumb\":{\"@id\":\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/#breadcrumb\"},\"inLanguage\":\"sk-SK\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/glycanostics.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/glycanostics.com\/#website\",\"url\":\"https:\/\/glycanostics.com\/\",\"name\":\"Glycanostics\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/glycanostics.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"sk-SK\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/glycanostics.com\/#\/schema\/person\/badee4cbfc54e0bf99314635b428c54d\",\"name\":\"cagan@seesame.com\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sk-SK\",\"@id\":\"https:\/\/glycanostics.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/7849fc5f0186381f2497fdb687e3b6dd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/7849fc5f0186381f2497fdb687e3b6dd?s=96&d=mm&r=g\",\"caption\":\"cagan@seesame.com\"},\"url\":\"https:\/\/glycanostics.com\/sk\/author\/caganseesame-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem - Glycanostics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/","og_locale":"sk_SK","og_type":"article","og_title":"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem - Glycanostics","og_description":"This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and [&hellip;]","og_url":"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/","og_site_name":"Glycanostics","article_published_time":"2022-02-07T17:46:53+00:00","article_modified_time":"2022-07-08T06:41:01+00:00","author":"cagan@seesame.com","twitter_card":"summary_large_image","twitter_misc":{"Autor":"cagan@seesame.com","Predpokladan\u00fd \u010das \u010d\u00edtania":"1 min\u00fata"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/","url":"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/","name":"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem - Glycanostics","isPartOf":{"@id":"https:\/\/glycanostics.com\/#website"},"datePublished":"2022-02-07T17:46:53+00:00","dateModified":"2022-07-08T06:41:01+00:00","author":{"@id":"https:\/\/glycanostics.com\/#\/schema\/person\/badee4cbfc54e0bf99314635b428c54d"},"breadcrumb":{"@id":"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/#breadcrumb"},"inLanguage":"sk-SK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/link.springer.com\/article\/10.1007\/s10719-020-09958-4\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/glycanostics.com\/"},{"@type":"ListItem","position":2,"name":"Anal\u00fdza s\u00e9rov\u00e9ho glyk\u00f3mu pomocou lekt\u00ednov\u00fdch mikro\u010dipov u pacientov s rakovinou prostaty \u2013 h\u013eadanie abnorm\u00e1lnych glykoforiem"}]},{"@type":"WebSite","@id":"https:\/\/glycanostics.com\/#website","url":"https:\/\/glycanostics.com\/","name":"Glycanostics","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/glycanostics.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"sk-SK"},{"@type":"Person","@id":"https:\/\/glycanostics.com\/#\/schema\/person\/badee4cbfc54e0bf99314635b428c54d","name":"cagan@seesame.com","image":{"@type":"ImageObject","inLanguage":"sk-SK","@id":"https:\/\/glycanostics.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7849fc5f0186381f2497fdb687e3b6dd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7849fc5f0186381f2497fdb687e3b6dd?s=96&d=mm&r=g","caption":"cagan@seesame.com"},"url":"https:\/\/glycanostics.com\/sk\/author\/caganseesame-com\/"}]}},"_links":{"self":[{"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/posts\/1849"}],"collection":[{"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/comments?post=1849"}],"version-history":[{"count":1,"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/posts\/1849\/revisions"}],"predecessor-version":[{"id":1850,"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/posts\/1849\/revisions\/1850"}],"wp:attachment":[{"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/media?parent=1849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/categories?post=1849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glycanostics.com\/sk\/wp-json\/wp\/v2\/tags?post=1849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}