Nové biomarkery rakoviny prostaty: etiológia, klinické účinky a použitie na účely detekcie
Validácia fPSA glykoprofilu ako biomarkera rakoviny prostaty ako spôsob vyhýbania sa zbytočným biopsiám a opakovaným biopsiám
Glykoprofilácia prostatického špecifického antigénu ako diagnostický a prognostický biomarker rakoviny prostaty
The initial part of this review details the controversy behind the use of a serological level of prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel biomarkers are in demand for PCa diagnostics, outperforming traditional PSA tests. The review provides a detailed and comprehensive summary that PSA glycoprofiling can effectively solve this problem, […]
Glykomika rakoviny prostaty: najaktuálnejšie informácie
Introduction: Prostate cancer (PCa) is a life-threatening disease affecting millions of men. The current best PCa biomarker (level of prostate-specific antigen in serum) lacks specificity for PCa diagnostics and this is why novel PCa biomarkers in addition to the conventional ones based on biomolecules such as DNA, RNA and proteins need to be identified. Areas […]
Detekcia N,N-diacetyllaktosamínu (LacdiNAc) s obsahom voľného prostatického špecifického antigénu na diagnostiku rakoviny prostaty v raných štádiách ochorenia a identifikáciu pacientov s karcinómom prostaty rezistentným na kastráciu
Prostate cancer (PCa) is one of the most common cancer types among men and also a common cause of death globally. With an increasing incidence, there is a need for low-cost, reliable biomarkers present in samples, which could be provided non-invasively (without a need to perform prostate biopsy). Glycosylation changes of free-PSA (fPSA) are considered […]
Analýza sérového glykómu pomocou lektínových mikročipov u pacientov s rakovinou prostaty – hľadanie abnormálnych glykoforiem
This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and […]
Pokročilý konfiguračný a analytický protokol pre impedimetrické biosenzory na glykoprofiláciu prostatického onkomarkera pomocou zlatých nanočastíc s magnetickým jadrom
In this paper several advances were implemented for glycoprofiling of prostate specific antigen (PSA), what can be applied for better prostate cancer (PCa) diagnostics in the future: 1) application of Au nanoshells with a magnetic core (MP@silica@Au); 2) use of surface plasmons of Au nanoshells with a magnetic core for spontaneous immobilization of zwitterionic molecules […]
Glykánové biomarkery rakoviny prsníka: ich súvislosť s metabolizmom nádorových buniek a perspektívne využitie v klinickej praxi
Introduction: Breast cancer (BCa) is the most common cancer type diagnosed in women and 5th most common cause of deaths among all cancer deaths despite the fact that screening program is at place. This is why novel diagnostics approaches are needed in order to decrease number of BCa cases and disease mortality. Areas covered: In […]
